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Benefits of gastric bypass surgery linked to changes in sweet taste preference

Kimberley Steele MD PhD, Principal Investigator and Director of Bariatric Research at Hopkins, was inspired to investigate this phenomenon after observing that her gastric bypass patients had a heightened sensitivity to sweet foods after surgery. Dr. Steele and her team of neuroscientists and imaging specialists hypothesized that the factors responsible for variation in weight loss following bariatric surgery may lie not just in the gut but also in the brain. Dr. Steele's team studied taste preferences for sugars and fats in patients prior to surgery and up to 3 months after Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG). While both RYGB and VSG procedures reduce the size of the stomach, RYGB also reroutes the progression of food through the intestines. Thus it alters many of the gut responses that would usually be triggered during digestion. Their preliminary data show that all patients experienced a decrease in their liking of sweet taste, but a more pro...